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Description of previously unrecognized syndrome of the prevalence of Focal Segmental Glomeruloscelerosis (FSG) in people born with a single kidney. This also sheds light on the pathogenesis of FSG. Kiprov D, Clovin R, McCluskey R. Focal and segmental glomerulosclerosis and proteinura associated with unilateral renal agenesis. Lab Invest 46:275, 1982. The first recognition that plasmapheresis affects not only the humoral but also the cellular immune system. Kiprov D, Morand P. The effect of plasmapheresis and immunosuppressive drug therapy on T-cell subsets as defined by monoclonal antibodies. J Clin Aphere 1-57, 1983. The first recognition of distinctive anti-lymphocyte factors in sera form patients with HIV infection. Kiprov D, Anderson RE, Morand P, Simpson D, Chermann JC, Levy J, Moss A. Antilymphocyte antibodies and seropositivity for retroviruses in high risk groups for AIDS. N Engl Med 312:1517, 1985 Kiprov D, Morand P. Lymphocyte subpopulations and mitogenic response studies in homosexuals with acquired immunodeficiency syndrome. Immunobiology 163:377, 1982. The first publication of a new immunologically-mediated syndrome affecting striated muscles. Kiprov D, Miller R. Polymyositis associated with benign monoclonal gammopathy. Lancet II: 1183-1186, 1984. Performed the first treatment (in humans) with the Prosorba immunoadsorption column (which subsequently was approved by the FDA). Kiprov D, Lippert R, Jones RF, et al. Extracorporeal perfusion of plasma over immobilized Protein A in a patient with Kaposi’s Sarcoma and acquired immunodeficiency. J Biol Response Modifers 3:330-346, 1985 The first description of an auto-immune neurologic syndrome in patients with predisposition for AIDS (today this will be HIV positive). Subsequent publications document the pathogenesis of the new syndrome and propose effective therapy- the novel use of the combination – plasmapheresis with IVIG. Lipkin I, Parry G, Kiprov D, et al. Inflammatory neuropathy in homosexual men with lymphadenopathy. Neurology 35:1479-1483, 1985. Kiprov D, Pfaell W, Parry G, Lang W, Miller R. Antibody-mediated peripheral neuropathies associated with ARC and AIDS: Successful treatment with plasmapheresis. J Clin Aphere 4:3-7, 1988. Miller R, Parry G, Lang W, Lippert R, Kiprov D. AIDS-related inflammatory Polyradiculoneuropathy: Successful treatment with plasma exchange. Neurol 36:206, 1986 Miller R, Parry G, Lang W, Lippert R, Kiprov D. AIDS-related inflammatory Polyradiculoneuropathy: Prediction of response to plasma exchange with electrophysiologic testing. Muscle & Nerve Sept. p.6, 1985 The first description of an auto-immune hematologic syndrome in AIDS and its treatment with Protein A immunoadsorption. Abrams D., Kiprov D, Volberding P. Isolated Thrombocytopenia in Homosexual Men- Longitudinal Follow-up, AIDS-associated Syndromes: Advances in Experimental Medicine and Biology 187: 117-122, 1985. Abrams D, Kiprov D, Geodert J, et al. Antibodies to Human T-Lymphotropic Virus Type III and development of the acquired immunodeficiency syndrome in homosexual men presenting with immune thrombocytopenia. Ann Intern Med 104:47-50, 1986. Mitterman A, Bertram D, Snyder H, Messerchmidt G, Diavarella D, Ainsworth S, Kiprov D, Arlin Z. Treatment of patients with HIV thrombocytopenia and hemolytic uremic syndrome with protein A (Prosorba Column) Immunoadsorption. Seminars in Hematology, 1989, 26:15-18 Conducted experiments which suggested that alloimmunization may prevent AIDS. Kiprov D, Hanson C, Sheppard H.: Alloimmunization to Prevent AIDS? Science, 11 February, 1994, vol. 263, p. 737 Published the most comprehensive study of adverse reactions of therapeutic apheresis. Dobri D. Kiprov, Patricia Golden, Regina Rohe, Sheila Smith, Jan Hofmann, and John Hunnicrat. Adverse Reactions Associated With Mobile Therapeutic Apheresis: Analysis of 17,940 procedures. JClinApheresis 16:130-133, 2001 |